Abstract: By using the hazard and operability method and combining with the thermal assessment results of fine chemical reaction, this paper made a safety analysis on an intermittent reactor production technology for producing lithium hexafluorophosphate by hydrogen fluoride solvent method. It identified the abnormal events of uncontrolled reaction, high temperature and high reactor pressure that existed during the fluorination and synthesis reactions of the process. Such events have triggered the leakage of highly toxic mediums leading to the actual risk of poisoning of personnel. Some measures and suggestions were put forward to reduce risks including intrinsic safety design, instrument interlocking control, abnormal condition protection and upgrading of personnel skills. The lays of protection analysis was adopted to further analyze the taken measures, which showed that the risk in the production process was acceptable.

Key words: fluoridation, synthesis, hazard and operability study/HAZOP, lays of protection analysis/LOPA, technical measure